This is a case report of a COVID-19 infection in a young male, previously healthy. The infection evolved with intense headache as the main symptom for 2 weeks. The headache was throbbing, severe, continuous, and worsened with efforts such as coughing. The patient presented no meningeal signs and neurological examination was normal. This is the first report of severe headache at the onset and main symptom of COVID-19 infection.