The therapeutic efficiency of ursodeoxycholic acid on Gilbert syndrome complicated by aplastic anemia: a series of case reports

• 作者: Jie Xu Xing Cui Yanyu Zhang
• 来源期刊: TMR现代中药
• 学科: 医学
• 关键词: Gilbert syndrome Unconjugated hyperbilirubinemia Ursodeoxycholic acid Aplastic anemia
• 年，卷（期）: 2021,（1）
• 页码范围: 1-6
• 页数: 6页
• 分类号: R55

摘要

Objective:To reduce the potential risk in aplastic anemia patients complicated with Gilbert syndrome,and find an effective treatment for the unconjugated hyperbilirubinemia.Material and Methods:The mutation of UGT1A1 gene was identified first via sequencing in patients with Gilbert syndrome complicated by aplastic anemia.Before the treatment for aplastic anemia,bilirubin and phenobarbitone tests were conducted.Patients were then treated for their primary disease and given ursodeoxycholic acid(UDCA)either with or without phenobarbitone.Results:The clinical practice of UDCA,which can alleviate increased bilirubin levels,did not affect the key treatments for aplastic anemia.Conclusions:These results indicate that Gilbert syndrome should be addressed when treating aplastic anemia.Furthermore,abnormal bilirubin levels can be controlled effectively by the UDCA treatment.