基本信息来源于合作网站,原文需代理用户跳转至来源网站获取       
摘要:
<strong>Background:</strong> Worldwide, prostatic adenocarcinoma is the most common tumour type among men. <strong>Aim:</strong> The aim of the present investigation was to develop a computer program to identify normal prostate biopsies and distinguish them from biopsies showing premalignant alterations (LGPIN, HGPIN) and adenocarcinoma. <strong>Method:</strong> Prostate biopsies (n = 2094) taken from 191 consecutive men during 2016 were stained with triple immunehistochemisty (antibodies to AMACRA, p63 and CK 5). Digital images of the biopsies were obtained with a scanning microscope and used to develop an automatic computer program (CelldaTM), intended to identify the morphological alterations. Visual microscopic finding was used as a reference. <strong>Result:</strong> Of the 191 men, 121 (63.4%) were diagnosed as having prostate adenocarcinoma and 70 (36.6%) as having no malignancy on the basis of the visual microscopy. In comparison, computer analysis identified 134 (70.2%) men with malignant disease and 57 (29.8%) with non-malignant disease after exclusion of artifacts, which constituted 10.4% of areas (indicated as malignant disease). Discrepant results were recorded in 15 (7.9%) men, and in 14 of these cases, HGPIN and areas suggestive of early invasion were common. Thus, it was uncertain whether these cases should be regarded as malignant or not. The agreement between the visual examination and the computer analysis was 92.1% (kappa value 0.823, sensitivity 99.2 and specificity was 0.80). <strong>Conclusion:</strong> It seems that computer analysis could serve as an adjunct to simplify and shorten the diagnostic procedure, first of all by ensuring that normal prostate biopsies are sorted out from those sent for visual microscopic evaluation.
推荐文章
Triple oxygen isotope constraints on the origin of ocean island basalts
Triple oxygen isotope
Helium isotope
Ocean island basalts
Mantle plume
Mantle heterogeneity
Crustal recycling
基于Triple Play业务的OFDM系统信道划分
OFDM系统
遗传算法
蚂蚁
最优化理论
三重播放业务
内容分析
关键词云
关键词热度
相关文献总数  
(/次)
(/年)
文献信息
篇名 Automatic Computer Analysis of Digital Images of Triple-Antibody-Stained Prostate Biopsies
来源期刊 泌尿学期刊(英文) 学科 医学
关键词 PROSTATE ADENOCARCINOMA LGPIN HGPIN ANTIBODY Computer Digital Images AUTOMATIC Analysis AMACR P504S Microscopy Scanning
年,卷(期) 2021,(1) 所属期刊栏目
研究方向 页码范围 17-29
页数 13页 分类号 R73
字数 语种
DOI
五维指标
传播情况
(/次)
(/年)
引文网络
引文网络
二级参考文献  (0)
共引文献  (0)
参考文献  (0)
节点文献
引证文献  (0)
同被引文献  (0)
二级引证文献  (0)
2021(0)
  • 参考文献(0)
  • 二级参考文献(0)
  • 引证文献(0)
  • 二级引证文献(0)
研究主题发展历程
节点文献
PROSTATE
ADENOCARCINOMA
LGPIN
HGPIN
ANTIBODY
Computer
Digital
Images
AUTOMATIC
Analysis
AMACR
P504S
Microscopy
Scanning
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
泌尿学期刊(英文)
季刊
2160-5440
武汉市江夏区汤逊湖北路38号光谷总部空间
出版文献量(篇)
324
总下载数(次)
0
论文1v1指导