基本信息来源于合作网站,原文需代理用户跳转至来源网站获取       
摘要:
The role of autologous hematopoietic stem cell transplantation(auto-HSCT)following high-dose chemotherapy has been validated and accepted as a standard treatment for patients with relapsed diffuse large B-cell lymphoma(DLBCL).However,its clinical efficacy as frontline therapy remains to be elucidated.This study aimed to examine the feasibility of frontline auto-HSCT for newly diagnosed intermediate/high-risk DLBCL patients.We retrospectively reviewed the data of 223 patients treated with frontline auto-HSCT or chemotherapy alone(year 2008-2014)from four hospitals.The median follow-up time was 29.4 months.Between the two treatment arms among the intermediate/high-risk DLBCL patients,the 3-year overall survival(OS)and progression-free survival(PFS)rates of patients given frontline auto-HSCT were 87.6%and 81.9%,respectively,and the chemotherapy-alone group showed 3-year OS and PFS rates of 64.9%and 59.59%,respectively.Compared with the chemotherapy-alone group,the frontline auto-HSCT could eliminate the adverse impact of non-germinal center B-cell(GCB)type.In addition,in the frontline auto-HSCT group,patients who achieved complete response(CR)at auto-HSCT had a longer survival time than those who did not achieve CR.Our results suggested that frontline auto-HSCT could improve the prognosis of intermediate/high-risk DLBCL patients.
推荐文章
Thermodynamic properties of San Carlos olivine at high temperature and high pressure
San Carlos olivine
Thermodynamic property
Thermal expansion
Heat capacity
Temperature gradient
High oxygen fugacity magma: implication for the destruction of the North China Craton
High oxygen fugacity
Decratonization
North China Craton
Plate subduction
用Cell组件生成测试报表
Cell组件
ActiveX控件
测试报表
探讨LTE small cell回传切换策略
LTE-small cell
CSG
回传切换
延迟
内容分析
关键词云
关键词热度
相关文献总数  
(/次)
(/年)
文献信息
篇名 High-dose Chemotherapy Combined with Autologous Hematopoietic Stem Cell Transplantation as Frontline Therapy for Intermediate/High-risk Diffuse Large B Cell Lymphoma
来源期刊 当代医学科学(英文) 学科
关键词
年,卷(期) 2021,(3) 所属期刊栏目 HEMATOLOGY COLUMN
研究方向 页码范围 465-473
页数 9页 分类号
字数 语种 英文
DOI 10.1007/s11596-021-2394-2
五维指标
传播情况
(/次)
(/年)
引文网络
引文网络
二级参考文献  (0)
共引文献  (0)
参考文献  (0)
节点文献
引证文献  (0)
同被引文献  (0)
二级引证文献  (0)
2021(0)
  • 参考文献(0)
  • 二级参考文献(0)
  • 引证文献(0)
  • 二级引证文献(0)
引文网络交叉学科
相关学者/机构
期刊影响力
华中科技大学学报(医学英德文版)
双月刊
1672-0733
42-1679/R
武汉市航空路13号同济医学院学报
eng
出版文献量(篇)
2952
总下载数(次)
0
  • 期刊分类
  • 期刊(年)
  • 期刊(期)
  • 期刊推荐
论文1v1指导