This paper aims at providing multi-source remote sensing images registered in geometric space for image fusion. Focusing on the characteristics and differences of multi-source remote sens-ing images, a feature-based registration algorithm is implemented. The key technologies include im-age scale-space for implementing multi-scale properties, Harris corner detection for keypoints ex-traction, and partial intensity invariant feature descriptor (PIIFD) for keypoints description. Even-tually, a multi-scale Harris-PIIFD image registration algorithm framework is proposed. The experi-mental results of fifteen sets of representative real data show that the algorithm has excellent, stable performance in multi-source remote sensing image registration, and can achieve accurate spa-tial alignment, which has strong practical application value and certain generalization ability.