Plasma melatonin levels in patients with diabetic retinopathy secondary to type 2 diabetes

• 作者: Hao-Hao Zhang Hong-Zhuo Liu Wei Zhu Wei-Wei Wan Wen-Cui Wan Yang Long
• 来源期刊: 世界糖尿病杂志:英文版(电子版)
• 学科: 医学
• 关键词: MELATONIN Diabetic retinopathy Case-control study Risk factor Type 2 diabetes
• 年，卷（期）: 2021,（2）
• 页码范围: 138-148
• 页数: 11页
• 分类号: R58

摘要

BACKGROUND Melatonin is reported to be related to diabetes mellitus(DM)risk;however,the effect of melatonin on diabetic retinopathy(DR)risk remains unclear.AIM The aim of this study was to determine the effect of melatonin on DR risk.METHODS A hospital-based case-control study was conducted from January 2020 to June 2020.DR was assessed using the Diabetic Retinopathy preferred practice pattern(PPP)-updated 2019 criteria.The participants were divided into the DM cases without DR(NDR)group,non-proliferative DR(NPDR)group and proliferative DR(PDR)group.Plasma melatonin concentration was detected with the enzymelinked immunosorbent assay kit.The relationship between plasma melatonin concentration and DR risk as well as severity was assessed.RESULTS It was found that plasma melatonin was 72.83±16.25,60.38±13.43,44.48±10.30 and 44.69±8.95 pg/mL in healthy controls,NDR group,NPDR and PDR group,respectively.In addition,it was found that plasma melatonin could be used as a potential diagnostic biomarker for DR(AUC=0.893,P<0.001).There was a significant positive relationship between total bilirubin and melatonin content(P<0.001)based on the correlation assay.Significant associations between total bilirubin and melatonin content were also detected in the NPDR(R2=0.360,P<0.001)and PDR(R2=0.183,P<0.001)groups.CONCLUSION The data obtained in this study demonstrated that plasma melatonin concentration was decreased in DR cases and could be used as a sensitive and specific marker for the diagnosis of DR.A significant positive relationship between total bilirubin and melatonin was detected.More related studies are required to understand the role of melatonin in DR.