Marchiafava-Bignami disease: A case report

• 作者: Monica Gupta Swati Garg Saurabh Gaba Rekha Gupta
• 来源期刊: 急性病杂志（英文版）
• 年，卷（期）: 2021,（3）
• 所属期刊栏目: Case Reports
• 页码范围: 126-129
• 页数: 4页
• 语种: 英文
• DOI: 10.4103/2221-6189.316863

摘要

Rationale: Clinicians encounter multiple alcohol-related illnesses in practice, and Marchiafava-Bignami disease is a rare and devastating entity among them. It is a toxic-demyelinating disease and seen in chronic alcoholics, although it may be occasionally observed in chronically malnourished teetotalers. The clinical presentations are diverse. The symptoms and signs are non-specific, and the onset can be acute or chronic. Patient's concerns: A 45-year-old right-handed patient suffered from alcohol use disorder with multiple non-specific neuropsychiatric manifestations. Diagnosis: Marchiafava-Bignami disease. Interventions: Thiamine, folate, vitamin B12, and steroid therapy. Outcome: The patient's behaviour was significantly improved but dysarthria and pyramidal signs persisted. He was left with permanent cognitive impairment. Lessons: Though prompt therapy may halt the demyelinating process in this disease, the treatment remains a challenge in clinical practice. The recognition of the neuro-radiologic features is crucial to establish an early diagnosis.