Organocatalytic asymmetric [3 + 3] annulation of isatin N,N'-cyclic azomethine imines with enals: Efficient approach to functionalized spiro N-heterocyclic oxindoles

• 来源期刊: 中国化学快报（英文版）
• 年，卷（期）: 2021,（2）
• 所属期刊栏目: Communications
• 页码范围: 672-675
• 页数: 4页
• 语种: 英文

摘要

An unprecedented chiral secondary amine-catalyzed[3 + 3]annulation of isatin N,N'-cyclic azomethine imines with α,β-unsaturated aldehydes was developed.This strategy allowed the construction of structurally novel spiro N-heterocyclic oxindole derivatives in good yields (up to 91％) and good to excellent enantioselectivities (up to ＞99％ ee),albeit with modest diastereoselectivities (up to 3.1∶1 dr).