The prognosis and short-term efficacy of corticosteroid therapy for COVID-19 patients

• 作者: Xinyu Jia Hengrui Zhang Yuan Ma Zhenzhen Wu Ningfei Ji Mao Huang
• 来源期刊: 生物医学研究杂志（英文版）
• 年，卷（期）: 2021,（3）
• 所属期刊栏目: LETTER TO THE EDITOR
• 页码范围: 247-252
• 页数: 6页
• 分类号: R511
• 语种: 英文

摘要

Dear Editor: Corticosteroids are widely used in the treatment of critically ill patients for active anti-inflammatory and immunosuppressive effects.However,the therapeutic effects of corticosteroid treatment are still disputable.Some studies have shown that corticosteroids can de-lay coronavirus RNA clearance[1],increase mortality[2]and cause adverse events[3].Conversely,other studies have confirmed the clinical value of corticosteroids in shortening hospital stays and decreasing the need for mechanical ventilation[4].Similarly,the use of corticosteroids in COVID-19 patients is controversial.Expert consensus in China has indicated that corticosteroids can be used as appropriate in critical patients[5].However,World Health Organization interim guidance opposes the routine use of corticosteroids in treatment[6].Therefore,we herein discussed the therapeutic effects of corticosteroids in COVID-19 patients based on the experience of front-line physicians and a meta-analysis.