Cortical Astrocyte-neuronal Metabolic Coupling Emerges as a Critical Modulator of Stress-induced Hopelessness

• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2021,（1）
• 所属期刊栏目: Research Highlights
• 页码范围: 132-134
• 页数: 3页
• 语种: 英文

摘要

Stress is a major risk factor for the development of mental illness,such as major depression disorder(MDD)[1].Despite decades of progress,including findings that stress-induced depression corresponds with numerous morpho-logical and functional neuronal changes within brain structures associated with cognition and mood,such as the medial prefrontal cortex(mPFC)[1-3],a thorough understanding of how stress induces the core symptoms of depression,such as hopelessness,is still lacking.In an exciting new paper in mice,Yin et al.show that astrocyte-neuronal metabolic coupling in the mPFC is critically involved in the stress-induced passive coping response in mice[4].