Atypical hematological manifestation of celiac disease:A case report of aplastic anemia in a 2-year-old child and review of the literature

• 作者: Thea von Graffenried Mattia Rizzi Michel Russo Andreas Nydegger Simon Kayemba-Kay's
• 来源期刊: 儿科学研究（英文）
• 年，卷（期）: 2021,（2）
• 所属期刊栏目: Case Report
• 页码范围: 159-162
• 页数: 4页
• 语种: 英文
• DOI: 10.1002/ped4.12267

摘要

Introduction:Celiac disease typically presents with symptoms of malabsorption,but extraintestinal manifestations are increasingly reported.Aplastic anemia as the mode of celiac disease presentation is extremely rare in children.Case presentation:We report a 2-year-old boy who presented with loose stools,loss of appetite,and bicytopenia with severe aregenerative normocytic anemia.Investigations,including bone marrow aspirate and biopsy,revealed aplastic anemia.Screening for malabsorption showed increased plasma concentrations of anti-transglutaminase and anti-gliadin antibodies.A duodenal biopsy confirmed the histologic features of celiac disease.The child received a packed red cell transfusion and was started on a gluten-free diet,with a very good prognosis and normalization of both his blood and histological parameters.To the best of our knowledge,our report is the sixth pediatric case in the literature.Conclusion:Screening for celiac disease should be performed in children with unexplained hematological abnormalities such as aplastic anemia with or without gastrointestinal symptoms.