In low-and middle-income countries, tertiary care hospitals frequently face an extremely heavy workload and shoulder an even heavier burden during the COVID-19 pandemic. Bach Mai Hospital (BMH), one of the leading tertiary hospitals in Vietnam, is on the frontline in the fierce battle against COVID-19. This letter aims to describe how BMH tackles the COVID-19 outbreak in the hospital-level battle, which could support policymakers in time-management and well-preparation for this unpredictable pandemic.