Effect of green tea consumption in treatment of mild to moderate depression in Iranian patients living with HIV:A double-blind randomized clinical trial

• 作者: Dehghan Manshadi Seyed Ali Mousavi Seyed Alireza Salehi Mohammad Reza Zebardast Jayran SeyedAlinaghi SeyedAhmad Rezazade Shams Ali Mirhoseinian Seyed Saeid Asadollahi-Amin Ali
• 来源期刊: 中草药（英文版）
• 年，卷（期）: 2021,（1）
• 所属期刊栏目: Original Articles
• 页码范围: 136-141
• 页数: 6页
• 语种: 英文

摘要

Objective:Depression affects people living with HIV(PLWH)compliance leading to poor control infection.Previous observational studies showed an anti-depression effect of green tea extract(GTE).The therapeu-tic effect of GTE on depression were investigated in PLWH receiving antiretroviral therapy(ART).Methods:Fifty PLWH on ART with diagnose of mild to moderate of depression,participated in a double-blind,placebo-controlled trial and underwent 12 weeks of treatment with either 400 mg GTE capsules or placebo twice daily.The Hamilton depression scale of patients was measured before,6 weeks and 12 weeks after treatment in two groups.The primary outcome measure was performed to evaluate the efficacy of GTE in improving depressive symptoms.Results:The mean of Hamilton score showed a significant difference between the two groups after 12 weeks(P-0.035).Repeated measures ANOVA test showed a significant effect for time x treatment interaction on the Hamilton mean score between the two groups(P-0.000).Conclusion:It seems the use of GTE capsules in PLWH on ART is safe and could lead to greater and more rapid improvement in depressive symptoms than placebo.Thus it can be considered as an alternative therapy for mild to moderate depression.Further studies with higher sample size and longer follow-up and comparisons with other antidepressive drugs are warranted.