Deletion of Glut1 in early postnatal cartilage reprograms chondrocytes toward enhanced glutamine oxidation

• 作者: Cuicui Wang Jun Ying Xiangfeng Niu Xiaofei Li Gary J.Patti Jie Shen Regis J.O'Keefe
• 来源期刊: 骨研究（英文版）
• 年，卷（期）: 2021,（4）
• 所属期刊栏目: ORIGINAL ARTICLES
• 页码范围: 507-520
• 页数: 14页
• 语种: 英文

摘要

INTRODUCTION Although they both originate from the embryonic common cartilage anlagen, the growth plate (GP) and articular cartilage (AC) separate and develop unique structures and functions shortly after birth as the primary and secondary ossification centers form and expand.1 During early postnatal development, GP chondro-cytes are metabolically active and undergo a highly orchestrated sequence of events including cell proliferation followed by hypertrophic maturation, similar to the chondrocyte differentia-tion process that occurs during embryonic skeletogenesis.2 Normal functioning of GP chondrocytes determines longitudinal bone growth, and the cartilaginous extracellular matrix provides a template for future bone formation.3 Perturbation of the normal sequence of cartilage development and growth pre- and postnatally is known to cause a number of skeletal dysplasias in humans.