Sinoatrial node pacemaker cells share dominant biological properties with glutamatergic neurons

• 作者: Dandan Liang Zhigang Xue Jinfeng Xue Duanyang Xie Ke Xiong Huixing Zhou Fulei Zhang Xuling Su Guanghua Wang Qicheng Zou Yi Liu Jian Yang Honghui Ma Luying Peng Chunyu Zeng Gang Li Li Wang Yi-Han Chen
• 来源期刊: 蛋白质与细胞
• 年，卷（期）: 2021,（7）
• 所属期刊栏目: SHORT ARTICLE
• 页码范围: 545-556
• 页数: 12页
• 语种: 英文

摘要

Activation of the heart normally begins in the sinoatrial node(SAN).Electrical impulses spontaneously released by SAN pacemaker cells(SANPCs)trigger the contrac-tion of the heart.However,the cellular nature of SANPCs remains controversial.Here,we report that SANPCs exhibit glutamatergic neuron-like properties.By com-paring the single-cell transcriptome of SANPCs with that of cells from primary visual cortex in mouse,we found that SANPCs co-clustered with cortical neurons.Tissue and cellular imaging confirmed that SANPCs contained key elements of glutamatergic neurotransmitter system,expressing genes encoding glutamate synthesis path-way(GIs),ionotropic and metabotropic glutamate receptors(Grina,Gria3,Grm1 and Grm5),and glutamate transporters(Slc17a7).SANPCs highly expressed cell