miR-20a Promotes the Axon Regeneration of DRG Neurons by Targeting Nr4a3

• 作者: Lili Zhao Leilei Gong Ping Li Jing Qin Lingchi Xu Qiyao Wei Huimin Xie Susu Mao Bin Yu Xiaosong Gu Songlin Zhou
• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2021,（4）
• 所属期刊栏目: Letters to the Editor
• 页码范围: 569-574
• 页数: 6页
• 语种: 英文

摘要

Dear Editor, The peripheral nervous system (PNS) regenerates more easily after injury than the central nervous system (CNS) [1].Sensory neurons in the L4-L6 dorsal root ganglia (DRGs) extend axons to form the sciatic nerve along with motor axons.The DRG neuron is one of the exceptional mature neurons whose axons can regenerate after injury.Following sciatic nerve crush or transection, these sensory neurons rapidly re-extend axons into the lesion site [2].The switch of DRG neurons from a transmitter to a regenerative state following injury requires the induction of widespread changes through transcription factors, epigenetic modifiers,and microRNAs.