A four-protein metabolon assembled by a small peptide protein creates the pentacyclic carbonate ring of aldgamycins

• 作者: Qiaozhen Wang Xiaolong Tang Ping Dai Chuanxi Wang Weiyang Zhang Guodong Chen Kui Hong Dan Hu Hao Gao Xinsheng Yao
• 来源期刊: 药学学报（英文版）
• 年，卷（期）: 2021,（2）
• 所属期刊栏目: Original articles
• 页码范围: 588-597
• 页数: 10页
• 语种: 英文

摘要

Organic carbonates(OCs)are a class of compounds featured by a carbonyl flanked by two alkoxy/aryloxy groups.They exist in either linear or cyclic forms,of which the majority encountered in nature adopt a pentacyclic structure.However,the enzymatic basis for pentacyclic carbonate ring for-mation remains elusive.Here,we reported that a four-protein metabolon(AlmUII-UV)assembled by a small peptide protein(AlmUV)appends a reactive N-hydroxylcarbamoyl moiety to the decarboxylated aldgamycins followed by a non-enzymatic condensation to give the pentacyclic carbonate ring.Our re-sults have documented an unprecedent mechanism for carbonate formation.