Microglial Calcium: An Exquisite Sensor for Neuronal Activity

• 作者: Jiyun Peng Bing-Xing Pan
• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2021,（4）
• 所属期刊栏目: Research Highlights
• 页码范围: 582-584
• 页数: 3页
• 语种: 英文

摘要

With the development of in vivo imaging techniques, it was discovered early in this century that microglia are highly dynamic even in the resting state [1].However, for over a decade, little has been learned about how the dynamic microglial motility is regulated, particularly in physiological and awake conditions [2].Two recent studies have made a breakthrough in this regard, showing that the motility of microglial processes is regulated by a shift in the state of neuronal activity, and the neurotransmitter norepinephrine (NE) is one of the key neuronal signal mediators through acting on microglial β2 receptors [3].Now, a new study has further revealed that Ca2+ microdomain signaling in microglial processes is an exquisite sensor for neuronal activity shifts, and this is associated with process extension/outgrowth (Fig.1).