Lateral transfer of mRNA and protein by migrasomes modifies the recipient cells

• 作者: Mingli Zhu Qin Zou Rongyao Huang Ying Li Xudong Xing Jianhuo Fang Liang Ma Lifei Li Xuerui Yang Li Yu
• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2021,（2）
• 所属期刊栏目: LETTERS TO THE EDITOR
• 页码范围: 237-240
• 页数: 4页
• 语种: 英文

摘要

Dear Editor, Migrasomes are recently discovered vesicular organelles which form on the retraction fibers(RFs)of migrating cells.1 Once detached from cells,migrasomes can rupture and release their luminal contents1 in a process named migracytosis.Recently,migrasomes have been shown to play an important role in zebrafish organ morphogenesis by releasing chemokine signals to defined regions of the embryo.2 Thus,migracytosis is considered as a major mechanism for migrasomes to carry out their functions.It has been frequently observed that intact migrasomes can be engulfed by surrounding cells,1 and this has been proposed as a potential mechanism for lateral transfer of cellular contents between cells.However,it is not clear whether the lateral transfer of cellular contents by migrasomes has functional consequences for the recipient cells.