TAPP1 Represses the Differentiation of Oligodendrocyte and its Deficiency Accelerates Myelin Regeneration after Demyelinating Injuries

• 作者: Ruyi Mei Jiaying Fu Chunxia Jiang Junlin Yang Kang Zheng Aifen Yang Mengsheng Qiu Xiaofeng Zhao
• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2021,（3）
• 所属期刊栏目: Letters to the Editor
• 页码范围: 385-388
• 页数: 4页
• 语种: 英文

摘要

Dear Editor, Myelin, the lipid-rich insulation that supports the integrity of axons, enables rapid conduction of nerve impulses and information flow to distant brain areas [1].Oligodendrocytes (OLs) are glial cells that myelinate axons with specialized lipid membrane extensions [2].OL progenitor cells (OPCs) arise from neural stem cells [3], and undergo proliferation before terminal differentiation and eventual myelination.Impairment at any stage of OL development can affect myelin formation.Dysfunction of OLs and CNS myelin causes devastating neurological disorders represented by multiple sclerosis [4].In addition, emerging evidence has revealed deficits in OLs and myelin in psychiatric disorders such as schizophrenia [5].Delineating the mechanisms that underlie OL differentiation is crucial to understand myelin formation, and is a critical prerequisite for the development of novel strategies against myelin-associated disorders.