Role of CD8 + T lymphocyte cells:Interplay with stromal cells in tumor microenvironment

• 作者: Qin Xie Jian Ding Yi Chen
• 来源期刊: 药学学报（英文版）
• 年，卷（期）: 2021,（6）
• 所属期刊栏目: Reviews
• 页码范围: 1365-1378
• 页数: 14页
• 语种: 英文

摘要

CD8+ T lymphocytes are pivotal cells in the host response to antitumor immunity.Tumor-driven microenvironments provide the conditions necessary for regulating infiltrating CD8+ T cells in favor of tumor survival,including weakening CD8+ T cell activation,driving tumor cells to impair im-mune attack,and recruiting other cells to reprogram the immune milieu.Also in tumor microenviron-ment,stromal cells exert immunosuppressive skills to avoid CD8+ T cell cytotoxicity.In this review,we explore the universal function and fate decision of infiltrated CD8+ T cells and highlight their anti-tumor response within various stromal architectures in the process of confronting neoantigen-specific tu-mor cells.Thus,this review provides a foundation for the development of antitumor therapy based on CD8+ T lymphocyte manipulation.