Stress-rupture properties of a Ni-base Re-containing single-crystal superalloy with three orientations have been tested under 900℃/445 MPa.An obvious anisotropy of stress-rupture property is attributed to orientation reliant deformation micro-structure.The good strength in[001]orientation is attributed to the rapid multiplication of dislocations active in horizontal channels and later γ' cutting via dislocations pair coupled with anti-phase boundary.The microtwin formation largely limits the strength and plasticity as a result of the continuous shearing across γ/γ' microstructure by{111}〈112〉slip activated in[011]orientation.The property in[111]orientation results mainly from the lateral cross-slip movements of the screw disloca-tions within connected matrix channels as well as the precipitate shearing by coplanar dislocations.Microcracks all initially originate from the interdendritic micropores in three orientations.The critical temperature of stress-rupture anisotropy could be increased by a high level of refractory solutes especially Re.