Subacute Toxicity of High-Dose Resveratrol and its Effect on Gut Microbiota in Healthy Male and Female Sprague-Dawley Rats

• 作者: LU Wei SONG Yan Hua XIA Yong ZHANG Shi Xin YAN Jun CAI De Lei XU Cai Ju
• 来源期刊: 生物医学与环境科学（英文版）
• 年，卷（期）: 2021,（7）
• 所属期刊栏目: Letters to the Editor
• 页码范围: 587-591,中插34-中插36
• 页数: 1页
• 语种: 英文
• DOI: 10.3967/bes2021.082

摘要

Resveratrol, 3,5,4-trihydroxystilbene, is a natural polyphenol phytoalexin found in various plant species and red wine. Although this compound has been widely used and extensively investigated, there are still uncertainties regarding the applicable dose range and relevant toxicities in experimental animals and humans. In fact, disparate doses (5–5,000 mg/day) and variable experimental settings related to the bioactivity studies of resveratrol have been used and investigated, which might lead to variations in readouts[1].