An Automatic HFO Detection Method Combining Visual Inspection Features with Multi-Domain Features

• 作者: Xiaochen Liu Lingli Hu Chenglin Xu Shuai Xu Shuang Wang Zhong Chen Jizhong Shen
• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2021,（6）
• 所属期刊栏目: Original Articles
• 页码范围: 777-788
• 页数: 12页
• 语种: 英文

摘要

As an important promising biomarker,high frequency oscillations (HFOs) can be used to track epileptic activity and localize epileptogenic zones.How-ever,visual marking of HFOs from a large amount of intracranial electroencephalogram (iEEG) data requires a great deal of time and effort from researchers,and is also very dependent on visual features and easily influenced by subjective factors.Therefore,we proposed an automatic epileptic HFO detection method based on visual features and non-intuitive multi-domain features.To eliminate the interference of continuous oscillatory activity in detected sporadic short HFO events,the iEEG signals adjacent to the detected events were set as the neighboring environ-mental range while the number of oscillations and the peak-valley differences were calculated as the environ-mental reference features.The proposed method was developed as a MatLab-based HFO detector to automati-cally detect HFOs in multi-channel,long-distance iEEG signals.The performance of our detector was evaluated on iEEG recordings from epileptic mice and patien(t)s with intractable epilepsy.More than 90％ of the HFO events detected by this method were confirmed by experts,while the average missed-detection rate was ＜ 10％.Compared with recent related research,the proposed method achieved a synchronous improvement of sensitivity and specificity,and a balance between low false-alarm rate and high detection rate.Detection results demonstrated that the proposed method performs well in sensitivity,specificity,and precision.As an auxiliary tool,our detector can greatly improve the efficiency of clinical experts in inspecting HFO events during the diagnosis and treatment of epilepsy.