Antioxidative and immunological effects of Cyclocarya paliurus polysaccharides on the spleen injury of diabetic rats

• 作者: XIA Xichao LI Bin QIU Ju TIAN Gang CHEN Changdong LA Ming ZHANG Ke QI Jinxu LI Yanyan GAO Huashan SHAO Xiangyang SU Congying WANG Mengqi OUYANG Jingfeng
• 来源期刊: 中医杂志（英文版）
• 年，卷（期）: 2021,（5）
• 所属期刊栏目: Research Articles
• 页码范围: 739-746
• 页数: 8页
• 语种: 英文
• DOI: 10.19852/j.cnki.jtcm.20210203.001

摘要

OBJEVTIVE:To investigate the effects of Cyclo-carya paliurus (C.paliurus) polysaccharides on the spleen injury of diabetic rats.METHODS.:Animals were divided into 6 groups,in-cluding normal group,model group,control group,low-dose group of C.paliurus polysaccharides treat-ment,middle-dose group of C.paliurus polysaccha-rides treatment and high-dose group of C.paliurus polysaccharides treatment.Histological analysis of spleen was analyzed using hematoxilin and eosin.Levels of biological parameters and anti-oxidative enzymes were determined by spectrophotometry.Interleukin-7 (IL-7) and IL-10 were measured by en-zyme-linked immunosorbent assay.RESULTS:Compared with that of model group,su-peroxide dismutase,catalase,glutathione peroxi-dase,glutathione reductase level increased 78.63％(P ＜ 0.05),51.76％ (P ＜ 0.05),2.95 times (P ＜ 0.01)and 41.11％ (P ＜ 0.05) in the high-dose group of C.paliurus polysaccharides treatment,respectively.IL-7 and IL-10 increase 1.66 (P ＜ 0.01) and 1.21 times (P ＜ 0.01) in the high-dose group of C.pali-urus polysaccharides treatment,respectively.CONCLUSION:It is suggested that C.paliurus poly-saccharides may play a protecting role for spleen in-jury of diabetic rats by enhancing the antioxidative ability and evaluating the immunity.