Extracellular vesicle activities regulating macrophage-and tissue-mediated injury and repair responses

• 作者: Qian Hu Christopher J.Lyon Jesse K.Fletcher Wenfu Tang Meihua Wan Tony Y.Hu
• 来源期刊: 药学学报（英文版）
• 年，卷（期）: 2021,（6）
• 所属期刊栏目: Reviews
• 页码范围: 1493-1512
• 页数: 20页
• 语种: 英文

摘要

Macrophages are typically identified as classically activated (M1) macrophages and alterna-tively activated (M2) macrophages,which respectively exhibit pro-and anti-inflammatory phenotypes,and the balance between these two subtypes plays a critical role in the regulation of tissue inflammation,injury,and repair processes.Recent studies indicate that tissue cells and macrophages interact via the release of small extracellular vesicles (EVs) in processes where EVs released by stressed tissue cells can promote the activation and polarization of adjacent macrophages which can in turn release EVs and factors that can promote cell stress and tissue inflammation and injury,and vice versa.This review discusses the roles of such EVs in regulating such interactions to influence tissue inflammation and injury in a number of acute and chronic inflammatory disease conditions,and the potential applications,advan-tage and concerns for using EV-based therapeutic approaches to treat such conditions,including their po-tential role of drug carriers for the treatment of infectious diseases.