Post-translational modification of KRAS:potential targets for cancer therapy

• 作者: Wei-hua Wang Tao Yuan Mei-jia Qian Fang-jie Yan Liu Yang Qiao-jun He Bo Yang Jin-jian Lu Hong Zhu
• 来源期刊: 中国药理学报（英文版）
• 年，卷（期）: 2021,（8）
• 所属期刊栏目: Review
• 页码范围: 1201-1211
• 页数: 11页
• 语种: 英文

摘要

Aberrant activation of the RAS superfamily is one of the critical factors in carcinogenesis.Among them,KRAS is the most frequently mutated one which has inspired extensive studies for developing approaches to intervention.Although the cognition toward KRAS remains far from complete,mounting evidence suggests that a variety of post-translational modifications regulate its activation and localization.In this review,we summarize the regulatory mode of post-translational modifications on KRAS including prenylation,post-prenylation,palmitoylation,ubiquitination,phosphorylation,SUMOylation,acetylation,nitrosylation,etc.We also highlight the recent studies targeting these modifications having exhibited potent anti-tumor activities.