MYRF:A Mysterious Membrane-Bound Transcription Factor Involved in Myelin Development and Human Diseases

• 作者: Hao Huang Fang Zhou Shiyou Zhou Mengsheng Qiu
• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2021,（6）
• 所属期刊栏目: Insights
• 页码范围: 881-884
• 页数: 4页
• 语种: 英文

摘要

The myelin regulatory factor gene (MYRF) encodes a protein evolutionarily conserved from invertebrates to vertebrates,representing a novel type of membrane-bound transcriptional factor (MBTF).In vertebrates,MYRF protein is required for myelin development and mainte-nance [1,2].Unlike other oligodendrocyte-specific tran-scription factors,it is initially synthesized as a conserved type-II membrane protein,containing a N-terminal proline-rich (Pro) domain,a putative yeast Ndt80-1ike DNA binding domain (DBD),two nuclear localization signal motifs,an intramolecular chaperone auto-processing (ICA)domain,a transmembrane domain,and a function-unknown C-terminal conserved (C) domain (Fig 1).Among these conserved domains,the DBD directly binds to the pro-moters of target genes,the transmembrane domain anchors MYRF to the endoplasmic reticulum (ER) membrane,and the ICA domain drives the homo-trimerization of MYRF protein and subsequently induces its self-cleavage via its intrinsic peptidase activity [3,4].