Copper catalyzed borylative cyclization of 3-arylallyl carbamoyl chloride with B2pin2:stereoselective synthesis of cis-2-aryl-3-boryl- γ-lactams

• 作者: Mei-Hua Shen Ting-Biao Wan Xiu-Rong Huang Yan Li Dan-Hua Qian Hua-Dong Xu Defeng Xu
• 来源期刊: 中国化学快报（英文版）
• 年，卷（期）: 2021,（7）
• 所属期刊栏目: Communications
• 页码范围: 2297-2300
• 页数: 4页
• 语种: 英文

摘要

Borylative cyclization of E-3-arylallyl carbamoyl chlorides is achieved through copper catalyzed intramolecular carboboration with B2pin2. 2-Aryl-3-boryl-γ-lactams are formed with exclusive cis-diastereoselectivity. CuBr-Dppp combination gives the best outcomes. The substrate scope is profiled.