Pharmacological interventions targeting nuclear factor-kappa B signaling in multiple sclerosis

• 作者: Kim M.A.De Kleijn Gerard J.M.Martens
• 来源期刊: 中国神经再生研究（英文版）
• 年，卷（期）: 2021,（10）
• 所属期刊栏目: Perspectives
• 页码范围: 2023-2025
• 页数: 3页
• 语种: 英文

摘要

Multiple sclerosis (MS) is an inflammatory neurodegenerative disease of the central nervous system (CNS). Pathological characteristics of the disease include activation of CNS-intrinsic immune cells, such as microglia and astrocytes, and loss of neuronal connections, myelin and blood-brain barrier (BBB) integrity as well as peripheral immune cell infiltration into the brain.