Hyperterpenoids A and B:Two pairs of unprecedented 6/6/4/6/6 polycyclic cyclobutane meroterpenoids with potent neuroprotective and anti-inflammatory activities from Hypericum beanii

• 作者: Bo Zhen Xinyue Suo Jun Dang Huilan Yue Yanduo Tao Jia-Jia Wang Li Li Ming-Bao Lin Qi Hou Wei-Ping Wang Xiao-Liang Wang Jian-Dong Jiang Teng-Fei Ji
• 来源期刊: 中国化学快报（英文版）
• 年，卷（期）: 2021,（7）
• 所属期刊栏目: Communications
• 页码范围: 2338-2341
• 页数: 4页
• 语种: 英文

摘要

Hyperterpenoid A (1) and B (2), two pairs of enantiomers, with an unprecedented 6/6/4/6/6 polycyclic skeleton, along with one known compoud hypermonone A (3) were isolated from Hypericum beanii. The racemate (±)-1 and (±)-2 were successfully separated into the two optically pure enantiomers (ee≥99％) using a preparative HPLC system. Their absolute configurations were elucidated by extensive spectroscopic analyses and single-crystal X-ray diffraction method. The related plausible biogenetic pathways were presented. Compound 1-3 showed significant neuroprotective activity and potential anti-inflammatory activity. The result that (+)-2 and (-)-2 presented different anti-inflammatory properties, may lead us to new discovery of structure activity relationship between racemates, enantiomers, and diastereomers, as well as further research regarding the binding of drugs to target proteins.