In this paper,a single-shot 360-degree cranial deformity detection system using digital image correlation (DIC) is presented to quickly obtain and detect accurate 3D data of infants' cra-nium. By introducing plane mirrors into a stereo 3D DIC measurement system,a multi-view 3D imaging model is established to convert 3D data from real and virtual perspectives into 360-degree 3D data of the tested infant cranium,achieving single-shot and panoramic 3D measurement. Exper-imental results showed that the performance and measurement accuracy of the proposed system can meet the requirements for cranial deformity detection,which provides a fast,accurate,and low-cost solution medically.