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摘要:
Isolating rare circulating tumor cells(CTCs)from blood is critical for the downstream analysis that is important in cancer-related research,diagnosis,and medicine,and efforts are ongoing to increase the efficiency and purity of CTC isolation in microfluidics.Reported in this paper is a two-stage integrated microfluidic chip for coarse-to-fine CTC isolation from whole blood.First,blood cells are removed by filtration using a micropore-array membrane,then CTCs and other cells that are trapped in the micropores are peeled off the membrane by a novel release method based on air-liquid interfacial tension,which significantly increases the recovery rate of CTCs.The second stage is CTC capture based on an on-chip dense immuno-magnetic-bead clump,which offers high capture efficiency and purity.Both the micropore filtration and immuno-magnetic-bead capture are validated and optimized experimentally.Overall,the integrated microfluidic chip can realize a recovery rate of 85.5%and a purity of 37.8%for rare cancer cells spiked in whole blood.
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篇名 On-chip circulating tumor cells isolation based on membrane filtration and immuno-magnetic bead clump capture
来源期刊 纳米技术与精密工程(英文版) 学科
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年,卷(期) 2022,(1) 所属期刊栏目 RESEARCH ARTICLES
研究方向 页码范围 24-34
页数 11页 分类号
字数 语种 英文
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纳米技术与精密工程(英文)
季刊
1672-6030
12-1458/03
天津市南开区卫津路92号
eng
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