Procalcitonin is expressed in osteoblasts and limits bone resorption through inhibition of macrophage migration during intermittent PTH treatment

• 作者: Anke Baranowsky Denise Jahn Shan Jiang Timur Yorgan Peter Ludewig Jessika Appelt Kai K.Albrecht Ellen Otto Paul Knapstein Antonia Donat Jack Winneberger Lana Rosenthal Paul K?hli Cordula Erdmann Melanie Fuchs Karl-Heinz Frosch Serafeim Tsitsilonis Michael Amling Thorsten Schinke Johannes Keller
• 来源期刊: 骨研究（英文版）
• 年，卷（期）: 2022,（1）
• 所属期刊栏目: ORIGINAL ARTICLES
• 页码范围: 107-121
• 页数: 15页
• 语种: 英文

摘要

INTRODUCTION Bone is a highly dynamic tissue that is remodeled throughout the lifespan. Bone turnover includes the degradation of old or damaged bone and the formation of new bone, which is carried out by two highly specialized cell types — osteoclasts and osteoblasts, respectively.1–2 Osteoblasts differentiate from mesenchymal stem cells, whereas osteoclasts form through the recruitment and fusion of macrophages.2 If the balance between bone formation and resorption is disturbed, osteoporosis, which is one of the most prevalent bone diseases in the aged population worldwide, may develop.