A metabolic acidity-activatable calcium phosphate probe with fluorescence signal amplification capabilities for non-invasive imaging of tumor malignancy

• 作者: Qian Jia Ruili Zhang Yongdong Wang Haohao Yan Zheng Li Yanbin Feng Yu Ji ZUO Yang Yang Yang Kanyi Pu Zhongliang Wang
• 来源期刊: 科学通报（英文版）
• 年，卷（期）: 2022,（3）
• 所属期刊栏目: Physical Sciences
• 页码范围: 288-298
• 页数: 11页
• 语种: 英文

摘要

Dysregulated energy metabolism has recently been recognized as an emerging hallmark of cancer.Tumor cells,which are characterized by abnormal glycolysis,exhibit a lower extracellular pH (6.5-7.0) than nor-mal tissues (7.2-7.4),providing a promising target for tumor-specific imaging and therapy.However,most pH-sensitive materials are unable to distinguish such a subtle pH difference owing to their wide and continuous pH-responsive range.In this study,we developed an efficient strategy for the fabrication of a tumor metabolic acidity-activatable calcium phosphate (CaP) fluorescent probe (termed MACaP9).Unlike traditional CaP-based biomedical nanomaterials,which only work within more acidic organelles,such as endosomes and lysosomes (pH 4.0-6.0),MACaP9 could not only specifically respond to the tumor extra-cellular pH but also rapidly convert pH variations into a distinct fluorescence signal to visually dis-tinguish tumor from normal tissues.The superior sensitivity and specificity of MACaP9 enabled high-contrast visualization of a broad range of tumors,as well as small tumor lesions.