A Triphenylphosphonium Functionalized AIE Conjugated Macro-cyclic Tetramaleimide for Mitochondrial-targeting Bioimaging

• 作者: Wei Zeng Mao-Hua Lin Ling-Yun Zhu Mei-Jin Lin
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2022,（1）
• 所属期刊栏目: Concise Reports
• 页码范围: 39-45
• 页数: 7页
• 语种: 英文
• DOI: 10.1002/cjoc.202100580

摘要

Development of subcellular organelle-targeted bioimaging probes is of great importance in the field of early detection of diseases and exploring the behaviors of subcellular organelles Herein,we present a triphenylphosphonium functionalized conjugated mac-rocyclic tetramaleimide (TPP-CMT) as a mitochondrial-targeting bioimaging probe.The core of TPP-CMT is obtained by connecting two pyrenes and two benzenes through four maleimides This unique structure endows TPP-CMT with exceptional far red/near-infrared aggregation-induced emission (FR/NIR-AIE)characteristics.TPP-CMT is an excellent fluorescent emitter in most solvents and even in solid states.The quantum yield of TPP-CMT was higher than 27％ when dissolved in common middle-polarity organic solvent and this value remained at 28.2％ in its solid state.The introduction of four triphenylphosphonium on maleimide po-sitions endows TPP-CMT with mitochondrial-targeting ability.Thanks to the FR/NIR-AIE characteristics and the mitochondri-al-targeting ability,this well-designed fluorescent probe was successfully employed for mitochondrial targeting bioimaging of HeLa and HepG2 cells.