Molecular mechanisms and roles of inflammatory responses on low-frequency residual hearing after cochlear implantation

• 作者: Juanjuan Gao Haijin Yi
• 来源期刊: 中华耳科学杂志（英文版）
• 年，卷（期）: 2022,（1）
• 所属期刊栏目: Review Articles
• 页码范围: 54-58
• 页数: 5页
• 语种: 英文

摘要

Preservation of low-frequency residual hearing is very important for combined electro-acoustic stimu-lation after cochlear implantation.However,in clinical practice,loss of low-frequency residual hearing often occurs after cochlear implantation and its mechanisms remain unclear.Factors affecting low-frequency residual hearing after cochlear implantation are one of the hot spots in current research.Inflammation induced by injury associated with cochlear implantation is deemed to be significant,as it may give rise to low-frequency residual hearing loss by interfering with the blood labyrinth barrier and neural synapses.Pathological changes along the pathway for low-frequency auditory signals trans-mission may include latent factors such as damage to neuroepithelial structures,synapses,stria vascu-laris and other ultrastructures.In this review,current research on mechanisms of low-frequency residual hearing loss after cochlear implantation and possible roles of inflammatory responses are summarized.