Clinical characteristics and related risk factors of disease severity in 101 COVID-19 patients hospitalized in Wuhan,China

• 作者: Xue-qing Liu Shan Xue Jia-bo Xu Heng Ge Qing Mao Xin-hui Xu Han-dong Jiang
• 来源期刊: 中国药理学报（英文版）
• 年，卷（期）: 2022,（1）
• 所属期刊栏目: Pulmonary Pharmacology
• 页码范围: 64-75
• 页数: 12页
• 语种: 英文

摘要

Coronavirus disease 2019(COVID-19)broke out in December 2019.Due its high morbility and mortality,it is necessary to summarize the clinical characteristics of COVID-19 patients to provide more theoretical basis for future treatment.In the current study,we conducted a retrospective analysis of the clinical characteristics of COVID-19 patients and explored the risk factors for the severity of illness.A total of 101 COVID-19 patients hospitalized in Leishenshan Hospital(Wuhan,China)was classified into three sub-types:moderate(n=47),severe(n=36),and critical(n=18);their clinical data were collected from the Electronic Medical Record.We showed that among the 101 COVID-19 patients,the median age was 62 years(IQR 51-74);50(49.5％)patients were accompanied by hypertension,while 25(24.8％)and 22(21.8％)patients suffered from diabetes and heart diseases,respectively,with complications.All patients were from Wuhan who had a definite history of exposure to the epidemic area.Multivariate logistic regression analysis revealed that older age,diabetes,chronic liver disease,percentage of neutrophils(N％)＞75％,CRP＞4 mg/L,D-dimer＞0.55 mg/L,IL-2R＞710 U/mL,IL-8＞62 pg/mL,and IL-10＞9.1 pg/mL were independent variables associated with severe COVID-19.In conclusion,we have identified the independent risk factors for the severity of COVID-19 pneumonia,including older age,diabetes,chronic liver disease,higher levels of N％,CRP,D-dimer,IL-2R,IL-8,and IL-10,providing evidence for more accurate risk prediction.