Realgar(α-As4S4)Treats Myelodysplastic Syndromes through Reducing DNA Hypermethylation

• 作者: ZHANG Miao ZHANG Jia-yi SUN Ming-qian LU Peng LIU Jian-xun
• 来源期刊: 中国结合医学杂志（英文版）
• 年，卷（期）: 2022,（3）
• 所属期刊栏目: Reviews
• 页码范围: 281-288
• 页数: 8页
• 语种: 英文
• DOI: 10.1007/s11655-020-3263-8

摘要

DNA hypermethylation is an epigenetic modification that plays a critical role in the oncogenesis of myelodysplastic syndromes(MDS).Aberrant DNA methylation represses the transcription of promotors of tumor suppressor genes,inducing gene silencing.Realgar(α-As4S4)is a traditional medicine used for the treatment of various diseases in the ancient time.Realgar was reported to have efficacy for acute promyelocytic leukemia(APL).It has been demonstrated that realgar could efficiently reduce DNA hypermethylation of MDS.This review discusses the mechanisms of realgar on inhibiting DNA hypermethylation of MDS,as well as the species and metabolisms of arsenic in vivo.