Gamichunggan汤对高血脂的作用

• 来源期刊: 中国药理学报（英文版）
• 学科: 医学
• 关键词: 高脂血症 甘油三酯 胆甾醇 O-酰基转移酶甾醇
• 年，卷（期）: 2003,（2）
• 所属期刊栏目: 研究原著
• 页码范围: 133-139
• 页数: 7页
• 分类号: R28
• 语种: 英文

摘要

AIM: To evaluate the therapeutic effects of Gamichunggantang (GCT) on hyperlipidemia through high cholesteroldiet model. GCT is an Oriental herbal medication, which has been used for the treatment of fatty liver, hyperlipi-demia or alcoholic liver disease in Daejeon University Oriental Hospital, Korea since 1999. METHODS:Rats werefed with high cholesterol diet for 4 weeks and GCT was administrated for 2 weeks from 2 weeks later in experi-mental days. The levels of serum total cholesterol, HDL-cholesterol, and triglyceride were analyzed every week.Absolute and relative liver weight to body, and histophathological changes were determined at last day. And, lipidmetabolism-related gene expressions (ACAT and DGAT) in liver tissue were analyzed by using RT-PCR. RESULTS:In GCT group, TG levels were reduced at 3 and 4 weeks after GCT administration (39.4 %, P＜0.05 and 36.3 %,P＜0.01 respectively). Total cholesterol levels also were reduced at 3 weeks (20.5 %, P＜0.05) and 4 weeks (35.86 %,P＜0.01) after GCT administration, but HDL-cholesterol levels were increased significantly (P＜0.05) at 3 weeks(14.7 %) and 4 weeks (25.5 %) compared with hyperlipidemia-induced group without GCT. In the GCT treatedgroup, liver weight was lower and lipid accumulation was decreased in histological finding. ACAT gene expressionwas suppressed compared with hyperlipidemia-induced group but not DGAT. CONCLUSION: GCT possessespreventive or therapeutic effects on diet-induced hyperlipidemia by inhibiting the intestinal absorption and storage ofexogenous and endogenous cholesterol.