螺旋状的 tomotherapy 能做整个大脑放射疗法和镭外科学吗？

• 作者: Cyrus Chargari Franois Campana Sofia Zefkili Youlia M Kirova
• 来源期刊: 世界放射学杂志：英文版（电子版）
• 学科: 医学
• 关键词: BRAIN METASTASES RADIOTHERAPY BREAST cancer TOMOTHERAPY
• 年，卷（期）: 2010,（4）
• 页码范围: 148-150
• 页数: 3页
• 分类号: R815

摘要

Whole brain radiotherapy (WBRT) remains the standard management of breast cancer patients with brain metastases, allowing for symptomatic improvement and good local control in most patients. However, its results remain suboptimal in terms of both efficacy and toxicity. In highly selected breast cancer patients, stereotaxic radiotherapy demonstrates a very good local control with a low toxicity. With the purpose of improving the efficacy/toxicity ratio, we report the association of integrated boost with WBRT in a breast cancer patient with brain metastases. Two and a half years after completion of helical tomotherapy (HT), the patient experienced clinical and radiological complete remission of her brain disease. No delayed toxicity occurred and the patient kept her hair without need of radiosurgical procedure. The HT provided a high dosimetric homogeneity, delivering integrated radiation boosts, and avoiding critical structures involved in long-term neurological toxicity. Further assessment is required and recruitment of breast cancer patients into clinical trials is encouraged.