bevacizumab 的 Intravitreal 注射独自或与为有斑点的浮肿的治疗的 triamcinolone acetonide 由中央网膜的静脉吸藏引起了

• 作者: and Jin-Ting Zhu Hai-Yan Wang Man-Hong Li Xiao Li Xiao-Na Su Yus-Sheng Wang Zi-Feng Zhang
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 关键词: BEVACIZUMAB TRIAMCINOLONE ACETONIDE MACULAR EDEMA central retinal vein occlusion
• 年，卷（期）: 2011,（1）
• 页码范围: 89-94
• 页数: 6页
• 分类号: R774

摘要

AIM:To compare the efficacy and safety of intravitreal bevacizumab alone versus bevacizumab combined with triamcinolone acetonide in eyes with macular edema caused by central retinal vein occlusion(CRVO) in Chinese patients.· METHODS:Seventy-five eyes of 75 patients were enrolled in this prospective,randomized,consecutive study.Thirty-six patients in group 1 were treated with an intravitreal injection of bevacizumab(1.25mg/0.05mL),and 39 patients in group 2 were treated with intravitreal bevacizumab(1.25mg/0.05mL) combined with triamcinolone acetonide(2mg/0.05mL).The main outcomes of the mean best corrected visual acuity(BCVA),central retinal thickness(CRT),and intraocular pressure(IOP) were measured.· RESULTS:In group 1,the mean BCVA improved from 37.78±6.14(baseline) to 48.06±3.86,46.48±4.77 and 44.18±5.78 at four,six and twelve weeks post-injection,respectively(P【0.01,P =0.03,P=0.04).In group 2,the mean BCVA improved from 35.92±6.20(baseline) to 50.69±4.22,48.76±5.59 and 45.70±6.56 at the same time points(P【0.01 each).However,there was no significant differences in the mean BCVA(F =0.043,P=0.836) and CRT(F=0.374,P =0.544) between these two groups.During the follow-up,five patients in group 1 and six patients in group 2 with high IOP were controlled with anti-glaucoma drugs.CONCLUSION:Intravitreal injection of bevacizumab alone or combined with triamcinolone acetonide has a short beneficial effect in Chinese patients with macular edema caused by CRVO,but there is no significant difference between the two groups.