Survival and death of endoplasmic-reticulum-stressed cells:Role of autophagy

• 作者: Jin-Ming Yang Yan Cheng
• 来源期刊: 世界生物化学杂志：英文版（电子版）
• 学科: 医学
• 关键词: Endoplasmic reticulum stress AUTOPHAGY APOPTOSIS CELL SURVIVAL CELL DEATH
• 年，卷（期）: 2011,（10）
• 页码范围: 226-231
• 页数: 6页
• 分类号: R363

摘要

Accumulation of unfolded proteins in the endoplasmic reticulum (ER) results in ER stress, which subsequently activates the unfolded protein response that induces a transcriptional program to alleviate the stress. Another cellular process that is activated during ER stress is autophagy, a mechanism of enclosing intracellular compo- nents in a double-membrane autophagosome, and then delivering it to the lysosome for degradation. Here, we discuss the role of autophagy in cellular response to ER stress, the signaling pathways linking ER stress to autophagy, and the possible implication of modulating autophagy in treatment of diseases such as cancer.