New antimyeloma drugs in spinal cord infiltration for multiple myeloma. Determination of lenalidomide in cerebrospinal fluid with ultrasensitive high-performance liquid chromatography

• 作者: Inmaculada Rapado Joaquín Martínez- López Juan José Lahuerta Laura Montejano Laura Pares María ángeles Montalbán
• 来源期刊: 化疗(英文)
• 学科: 医学
• 关键词: LENALIDOMIDE Multiple MYELOMA Spinal CORD INFILTRATION High-Performance Liquid Chromatography
• 年，卷（期）: 2012,（2）
• 页码范围: 11-13
• 页数: 3页
• 分类号: R73

摘要

A 64-year-old woman with IgA kappa multiple myeloma was treated with thalidomide-dexa- methasone. Due to progression of the disease, bortezomib, doxorubicin and dexamethasone were administered, followed by autologous stem cell transplantation. Although near-complete remission was achieved, 5 months later, neuro- logical symptoms appeared and the patient was diagnosed with multiple myeloma with cells in- filtrating the spinal cord. Bis-chloronitrosourea, bortezomib and lenalidomide were then admin- istered and although the patient remained neu- rologically asymptomatic, she died 3 months later becausee of disease progression. Lena- lidomide entered into the cerebrospinal fluid (confirmed by ultrasensitive high-performance liquid chromatography), although did not im- prove the poor prognosis of multiple myeloma involving the central nervous system.