Do We Have a Biocompatible Peritoneal Dialysis Fluid?

• 作者: Batya Kristal Dunia Hassan Fadi Hassan Kamal Hassan Khalid Khazim Shadi Hassan
• 来源期刊: 肾脏病(英文)
• 学科: 医学
• 关键词: ICODEXTRIN AMINO ACIDS PDF Homocyteine Carbohydrates LIPIDS Inflammation
• 年，卷（期）: 2012,（3）
• 页码范围: 29-34
• 页数: 6页
• 分类号: R73

摘要

Objective: Cardiovascular disease remains the leading cause of morbidity and mortality in patients on maintenance dialysis. Diabetes mellitus, dyslipidemia, hypertension, inflammation and hyperhomocyteinemia are major cardiovascular risk factors. Aim: to evaluate the effects of Icodextrin and amino acid peritoneal dialysis fluid (AAPDF) on these major cardiovascular risk factors looking for a more biocompatible PDF formula. Methods: 24 adult stable peritoneal dialysis patients were included in the study. 12 patients received 2L Icodextrin and other 12 patients received 2L AAPDF in their dialysis prescription for 8 weeks. Results: Icodextrin decreased fasting plasma glucose (p Conclusions: A biocompatible PDF should provide not only adequate dialysis and ultrafiltration but should also improve nutritional and metabolic status, blood pressure control and reduce inflammation and plasma homocyteine.