Natural compounds as anticancer agents:Experimental evidence

• 作者: Jiao Wang Yang-Fu Jiang
• 来源期刊: 世界实验医学杂志
• 学科: 医学
• 关键词: Cancer CHEMOPREVENTION Natural agents (-)-Epigallocatechin-3-gallate RESVERATROL CURCUMIN Vitamin D INDOLE-3-CARBINOL
• 年，卷（期）: 2012,（3）
• 页码范围: 45-57
• 页数: 13页
• 分类号: R

摘要

Cancer prevention research has drawn much attention worldwide.It is believed that some types of cancer can be prevented by following a healthy life style.Cancer chemoprevention by either natural or synthetic agents is a promising route towards lowering cancer incidence.In recent years,the concept of cancer chemoprevention has evolved greatly.Experimental studies in animal models demonstrate that the reversal or suppression of premalignant lesions by chemopreventive agents is achievable.Natural occurring agents such as dietary phytochemicals,tea polyphenols and resveratrol show chemopreventive activity in animal models.Moreover,clinical trials for testing the safety and efficacy of a variety of natural agents in preventing or treating human malignancy have been ongoing.Here,we summarize experimental data on the chemopreventive or tumor suppressive effects of several natural compounds including curcumin,(-)-epigallocatechin-3-gallate,resveratrol,indole-3-carbinol,and vitamin D.