为从乳癌的内部乳房的淋巴节点转移的新奇的根除的高剂量的率 brachytherapy

• 作者: Hirokazu Tanino Kazushi Kishi Morio Sato Shintaro Shirai Tetsuo Sonomura Yasutaka Noda Yoshitaka Okamura
• 来源期刊: 世界放射学杂志：英文版（电子版）
• 学科: 医学
• 关键词: BRACHYTHERAPY HYALURONATE Internal MAMMARY LYMPH node Metastasis Skin PRESERVATION Breast cancer ORGAN at risk
• 年，卷（期）: 2012,（11）
• 页码范围: 443-449
• 页数: 7页
• 分类号: R737.9

摘要

AIM:To develop a method of delivering an eradicative high radiotherapeutic dose safely preserving the surrounding skin in the treatment of internal mammary lymph node metastasis (IMLNM) of breast cancer. METHODS:We report a 38-year-old female patient with a solo IMLNM showing no response to 60 Gy in 2.5 Gy fractions of external beam radiotherapy. To eradicate this tumor, a boost brachytherapy plan was created after percutaneous insertion of an applicator needle into the IMLNM lesion avoiding the pleura and vessels under ultrasound monitoring. According to the dose distribution, the required thickness of a spacer between the skin and the tumor was determined, and hyaluronic gel was injected up to this thickness under ultrasound monitoring. We evaluated skin doses, target doses and clinical outcome. RESULTS:All procedures were performed easily. Sixteen Gy (34.7 Gy equivalent in 2 Gy fractions calculated by the linear quadratic model at α/β = 10:EQ 2, α/β = 10 , cumulative total was 101.9 Gy EQ 10) to 100% of the target volume was irradiated with cumulative maximum skin dose of 70 Gy EQ 2, α/β = 3 which was 98.7 Gy EQ 2, α/β = 3 without spacer. No procedure related-or late complications and no local recurrence at the treated site were observed for three years until expiration. CONCLUSION:We consider that this procedure will provide an eradicative high-dose irradiation to IMLNM of breast cancer, preserving skin from overdose complications.