This paper wrote about the cultural differences. There are four dimensions: power distance, uncertainty avoidance, individualism and masculinity. After that, paper talked about the intercultural communication, which contains language, non-verbal communication, time and space concept. Then talked different cultures do cause problems in business. To avoid misunderstanding and clashes, the international managers should realize and understand the different cultures, adapt themselves to fit into the business environment in order to get the best achievement in business.