X chromosome inactivation and autoimmune diseases

• 作者: Ghazi Chabchoub
• 来源期刊: 世界风湿病学杂志
• 学科: 医学
• 关键词: X CHROMOSOME X CHROMOSOME INACTIVATION AUTOIMMUNE DISEASES
• 年，卷（期）: 2013,（3）
• 页码范围: 12-15
• 页数: 4页
• 分类号: R

摘要

The pathogenesis of autoimmune diseases(AIDs)is characterized by a female preponderance.The causes for this sex imbalance are based on several hypotheses.One of the most intriguing hypotheses is related to an X chromosome inactivation(XCI)process.Females are mosaics for two cell populations,one with the maternal and one with the paternal X as the active chromosome.Skewed XCI is often defined as a pattern where 80%or more of the cells show a preferential inactivation of one X chromosome.The role of skewed XCI has been questioned in the pathogenesis of several AIDs,such as autoimmune thyroid diseases and rheumatoid arthritis.