Investigation of the Holding Capability of the Dielectrophoretic Gate and Sorter System for Biodetection

• 作者: Dawn J. Bennett Hongjun Song Ziliang Cai
• 来源期刊: 生物传感器(英文)
• 学科: 医学
• 关键词: Biodetection Dielectrophoresis Microfludic SYSTEM PARTICLE SEPARATION
• 年，卷（期）: 2013,（2）
• 页码范围: 65-75
• 页数: 11页
• 分类号: R73

摘要

The dielectrophoretic gate and sorter system has been widely applied for preconcentrating and sorting of bioparticles for biodetection. In such systems, the dielectrophoretic force is generated by applying an AC electric field on the three dimensional electrode systems (containing a pair of electrodes on the top and bottom of the channel). Particles are held and sorted by balancing the DEP force with the hydrodynamic drag force. The holding capability is very important for such systems because it determines the preconcentration and sorting efficiency. In this paper, we investigate the holding capability of a simple dielectrophoretic gate system. Initially, a three dimensional numerical scheme was introduced to estimate the holding capability and was further validated by comparing with experimental results. Second, we systematically investigated the effects of the phase difference between the top and bottom electrodes;the height and width of the channel, and the relative position and size of top and bottom electrodes. The results demonstrated that the maximum holding capability is reached when the phase difference between the top and bottom electrodes is around 180o. The results also show that the holding capability varied with the size and relative position of electrodes on the top and bottom, and the maximum holding capability is obtained when the top and bottom electrodes had the same size and the centers of both electrodes overlapped.